Anti-neuroinflammation effects of transcutaneous auricular vagus nerve stimulation against depression-like behaviors via hypothalamic α7nAchR/JAK2/STAT3/NF-κB pathway in rats exposed to chronic unpredictable mild stress.
Yu ChenYue ZhangJunying WangShaoyuan LiYifei WangZixuan ZhangJinling ZhangChen XinYu WangPei-Jing RongPublished in: CNS neuroscience & therapeutics (2023)
The hypothalamic α7nAchR/JAK2/STAT3/NF-κB signaling pathway may play an important role in the antidepressant-like behavior of taVNS.
Keyphrases
- signaling pathway
- lps induced
- pi k akt
- stress induced
- induced apoptosis
- epithelial mesenchymal transition
- inflammatory response
- depressive symptoms
- major depressive disorder
- traumatic brain injury
- nuclear factor
- lipopolysaccharide induced
- oxidative stress
- cell proliferation
- physical activity
- cognitive impairment
- subarachnoid hemorrhage
- brain injury
- endoplasmic reticulum stress