Cuproptosis engages in c-Myc-mediated breast cancer stemness.
Runtian WangKun XuQin ChenQin HuJian ZhangXiaoxiang GuanPublished in: Journal of translational medicine (2023)
In addition to previous reports on its oncogenic roles, c-Myc showed significant correlation to stemness phenotype and copper-induced cell toxicity in breast cancer tissues. Moreover, transcriptomics data demonstrated that pro-tumoral cuproptosis biomarkers had putative positive association with cancer stemness. This research combined clinical samples with large-scale bioinformatic analysis, covered description and deduction, bridged classic oncogenic mechanisms to innovative opportunities, and inspired the development of copper-based nanomaterials in targeting highly heterogeneous tumors.
Keyphrases
- stem cells
- epithelial mesenchymal transition
- single cell
- oxide nanoparticles
- transcription factor
- papillary thyroid
- cancer stem cells
- oxidative stress
- diabetic rats
- high glucose
- electronic health record
- cell therapy
- squamous cell
- anti inflammatory
- emergency department
- signaling pathway
- young adults
- data analysis
- lymph node metastasis
- big data
- drug induced
- squamous cell carcinoma
- mesenchymal stem cells
- adverse drug
- machine learning
- endothelial cells
- stress induced