Login / Signup

Rationale and Criteria for a COVID-19 Model Framework.

Francesco MessinaChiara MontaldoIsabella AbbateManuela AntonioliVeronica BordoniGiulia MatusaliAlessandra SacchiEmanuela GiombiniGian Maria FimiaMauro PiacentiniMaria Rosaria CapobianchiFrancesco Nicola LauriaGiuseppe Ippolitonull On Behalf Of Covid-Scoping Review Working Group
Published in: Viruses (2021)
Complex systems are inherently multilevel and multiscale systems. The infectious disease system is considered a complex system resulting from the interaction between three sub-systems (host, pathogen, and environment) organized into a hierarchical structure, ranging from the cellular to the macro-ecosystem level, with multiscales. Therefore, to describe infectious disease phenomena that change through time and space and at different scales, we built a model framework where infectious disease must be considered the set of biological responses of human hosts to pathogens, with biological pathways shared with other pathologies in an ecological interaction context. In this paper, we aimed to design a framework for building a disease model for COVID-19 based on current literature evidence. The model was set up by identifying the molecular pathophysiology related to the COVID-19 phenotypes, collecting the mechanistic knowledge scattered across scientific literature and bioinformatic databases, and integrating it using a logical/conceptual model systems biology. The model framework building process began from the results of a domain-based literature review regarding a multiomics approach to COVID-19. This evidence allowed us to define a framework of COVID-19 conceptual model and to report all concepts in a multilevel and multiscale structure. The same interdisciplinary working groups that carried out the scoping review were involved. The conclusive result is a conceptual method to design multiscale models of infectious diseases. The methodology, applied in this paper, is a set of partially ordered research and development activities that result in a COVID-19 multiscale model.
Keyphrases
  • infectious diseases
  • coronavirus disease
  • sars cov
  • healthcare
  • systematic review
  • endothelial cells
  • clinical trial
  • risk assessment
  • candida albicans
  • human health
  • single molecule
  • induced pluripotent stem cells