A High-Fat High-Fructose Diet Dysregulates the Homeostatic Crosstalk Between Gut Microbiome, Metabolome, and Immunity in an Experimental Model of Obesity.
Kun-Ping LiMin YuanYong-Lin WuMiguel PinedaChu-Mei ZhangYan-Fen ChenZhi-Quan ChenXiang-Lu RongJeremy E TurnbullJiao GuoPublished in: Molecular nutrition & food research (2022)
HFF-intake disturbs gut flora homeostasis. Crosstalk between gut microbiota and innate immune system mediates hepatic metaflammation in obese rats, associated with LPS-TLR4 signaling pathway activation. Moreover, α-hydroxyisobutyric acid and some other organic acids may play a role as messengers in the liver-gut axis.
Keyphrases
- weight loss
- immune response
- signaling pathway
- inflammatory response
- metabolic syndrome
- bariatric surgery
- weight gain
- type diabetes
- toll like receptor
- insulin resistance
- pi k akt
- adipose tissue
- physical activity
- obese patients
- high fat diet induced
- anti inflammatory
- induced apoptosis
- nuclear factor
- body mass index
- cell proliferation
- water soluble
- endoplasmic reticulum stress