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A High-Fat High-Fructose Diet Dysregulates the Homeostatic Crosstalk Between Gut Microbiome, Metabolome, and Immunity in an Experimental Model of Obesity.

Kun-Ping LiMin YuanYong-Lin WuMiguel PinedaChu-Mei ZhangYan-Fen ChenZhi-Quan ChenXiang-Lu RongJeremy E TurnbullJiao Guo
Published in: Molecular nutrition & food research (2022)
HFF-intake disturbs gut flora homeostasis. Crosstalk between gut microbiota and innate immune system mediates hepatic metaflammation in obese rats, associated with LPS-TLR4 signaling pathway activation. Moreover, α-hydroxyisobutyric acid and some other organic acids may play a role as messengers in the liver-gut axis.
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