Human papillomavirus and p53 status define three types of vulvar squamous cell carcinomas with distinct clinical, pathological, and prognostic features.
Núria CarrerasAdela SacoMarta Del PinoLorena MarimonRicardo López Del CampoCarolina ManzottiPere FustéClàudia PumarolaAureli TornéAdriana GarciaNatalia RakislovaPublished in: Histopathology (2023)
The association of HPV and p53 status have prognostic implications, reinforcing a three-tier molecular classification of VSCC (HPV-associated VSCC, HPV-independent VSCC with normal p53, HPV-independent VSCC with abnormal p53).