Clinical utility of p16/Ki67 dual-stain cytology for detection of cervical intraepithelial neoplasia grade two or worse in women with a transformation zone type 3: A cross-sectional study.

Line Winther GustafsonMette TranbergPia Nørgaard ChristensenRikke BrøndumNicolas WentzensenMegan A ClarkeBerit AndersenLone Kjeld PetersenPinar BorAnne Hammer

Published in: BJOG : an international journal of obstetrics and gynaecology (2022)

Dual stain may be a valuable risk marker to guide clinical management of women with a TZ3. The superior NPV of DS suggests that a diagnostic excision may safely be avoided in DS-negative women.

Keyphrases

high grade
polycystic ovary syndrome
physical activity
fine needle aspiration
loop mediated isothermal amplification
neoadjuvant chemotherapy
pregnancy outcomes
breast cancer risk
risk factors
type diabetes
pregnant women
ultrasound guided
lymph node