Shared genetic architecture between type 2 diabetes and COVID-19 severity.

J NiL-J QiuK-J YinG-M ChenHai-Feng Pan

Published in: Journal of endocrinological investigation (2022)

Our findings further confirm the comorbidity of T2D and COVID-19 severity, but a non-causal impact of T2D on severe COVID-19. Shared genetically modulated molecular mechanisms underlying the co-occurrence of the two disorders are crucial for identifying therapeutic targets.

Keyphrases

coronavirus disease
sars cov
type diabetes
respiratory syndrome coronavirus
cardiovascular disease
early onset
adipose tissue
genome wide
metabolic syndrome
gene expression
copy number
weight loss