Gut microbiota accelerates cisplatin-induced acute liver injury associated with robust inflammation and oxidative stress in mice.
Shenhai GongYinglin FengYunong ZengHuanrui ZhangMeiping PanFangjie HeRong WuJingrui ChenJiuling LuSiyou ZhangSonghua YuanSong QuanPublished in: Journal of translational medicine (2021)
This study elucidated the mechanism by which gut microbiota mediates cisplatin hepatotoxicity through enhanced inflammatory response and oxidative stress. This knowledge may help develop novel therapeutic approaches that involve targeting the composition and metabolites of microbiota.
Keyphrases
- drug induced
- liver injury
- oxidative stress
- inflammatory response
- dna damage
- ischemia reperfusion injury
- diabetic rats
- induced apoptosis
- healthcare
- liver failure
- lipopolysaccharide induced
- cancer therapy
- high fat diet induced
- metabolic syndrome
- heat shock
- lps induced
- respiratory failure
- adipose tissue
- immune response
- signaling pathway
- insulin resistance
- acute respiratory distress syndrome
- aortic dissection
- extracorporeal membrane oxygenation