Comparison of next-generation sequencing and cobas EGFR mutation test v2 in detecting EGFR mutations.

Shuji MurakamiTomoyuki YokoseKanako ShinadaTestuya IsakaKengo KatakuraRyouta UshioTetsuro KondoTerufumi KatoHiroyuki ItoHaruhiro Saito

Published in: Thoracic cancer (2022)

The success rate of ODxTT is slightly inferior to that of cobas EGFR. ODxTT shared a high concordance rate and k-coefficient with cobas EGFR in detecting EGFR mutations, but discordant results between the two tests were observed in a few cases, mainly due to the difference of detectable EGFR variants.

Keyphrases

small cell lung cancer
epidermal growth factor receptor
tyrosine kinase
copy number
gene expression