Efficacy and safety of antibiotics targeting Gram-negative bacteria in nosocomial pneumonia: a systematic review and Bayesian network meta-analysis.

David Luque PazDara CheanPierre TattevinDamien Luque PazBetsega Assefa BayehAchille KouatchetDelphine DouilletJérémie Riou

Published in: Annals of intensive care (2024)

This network meta-analysis suggests that most antibiotic regimens, including new combinations and cefiderocol, have similar efficacy and safety in treating susceptible Gram-negative bacilli in NP. Further studies are necessary for NP caused by multidrug-resistant bacteria. Registration PROSPERO CRD42021226603.

Keyphrases

gram negative
multidrug resistant
systematic review
acinetobacter baumannii
drug resistant
case control
klebsiella pneumoniae
meta analyses
escherichia coli
cancer therapy
intensive care unit
drug delivery