Molecular and Spatial Signatures of Mouse Embryonic Endothelial Cells at Single-Cell Resolution.

Jian ChenXiaoran Zhang Daniel M DeLaughterMichael A TrembleyShaila Saifee Feng Xiao Jiehui Chen Pingzhu Zhou Christine E Seidman Jonathan G Seidman William T Pu

Published in: Circulation research (2024)

Our results provide a spatiotemporal map of embryonic EC heterogeneity at single-cell resolution and demonstrate that the diversity of ECs in the embryo arises from both tissue origin and vascular-bed position. Developing aECs and vECs share common venous-featured capillary precursors and are regulated by distinct transcriptional regulatory networks.

Keyphrases

single cell
rna seq
endothelial cells
single molecule
transcription factor
high throughput
gene expression
genome wide
high glucose