The Mammalian KU70 C-terminus SAP Domain Is Required to Repair Exogenous DNA Damage.

Yuan WangMichael S CzapHailey KimHuimei LuJingmei LiuYokechen ChangPeter J RomanienkoCristina MontagnaZhiyuan Shen

Published in: bioRxiv : the preprint server for biology (2024)

Generation of a novel transgenic mouse line lacking the C-terminal conserved KU70-SAP domainKU70-SAP defends against exogenous DSBs, but unessential for development and V(D)J recombinationKU70-SAP aids in recruiting and retaining NHEJ components, such as LIG4, to DSB sites.

Keyphrases

dna damage
oxidative stress
transcription factor
dna repair