Leukocyte Telomere Length, DNA Oxidation, and Risk of Lower-Extremity Amputation in Patients With Long-standing Type 1 Diabetes.

Manuel SanchezSophie HoangCaroline KannengiesserLouis PotierSamy Hadjadj Michel Marre Ronan Roussel Gilberto Velho Kamel Mohammedi

Published in: Diabetes care (2020)

We report the first independent association between LTL shortening and excess risk of LEA in type 1 diabetes. High plasma 8-OHdG was also associated with incident LEA but partly dependent on cofounding variables.

Keyphrases

type diabetes
cardiovascular disease
glycemic control
insulin resistance
circulating tumor
single molecule
hydrogen peroxide
cell free
peripheral blood
weight loss
circulating tumor cells