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Metal-free efficient synthesis of aryl sulfonamides from N -hydroxy sulfonamide and amines.

E V Venkat Shivaji RamaraoJayshree Nandkumar SolankeRana ChatterjeeSavita GatVasudevan DhayalanRambabu Dandela
Published in: Organic & biomolecular chemistry (2024)
A simple and novel approach has been developed for the synthesis of sulfonamides from N -hydroxy sulfonamide. Notably, the iodine- tert -butyl hydroperoxide (TBHP) system efficiently promoted the sulfonylation reactions of N -hydroxy sulfonamides and amines via the oxidative cleavage of an S-N bond. A variety of aryl sulfonamides were prepared in moderate to good yields using readily available starting materials and the biomass-derived 2-MeTHF solvent. The present method has the advantages of using metal-free reagents, an eco-friendly medium, cost-effective reagents, wide substrate scope, and mild conditions.
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