D-Mannose prevents bone loss under weightlessness.

Ranli GuHao LiuMenglong HuYuan ZhuXuenan LiuFeilong WangLikun WuDanyang SongYunsong Liu

Published in: Journal of translational medicine (2023)

D-mannose protected against bone loss and UTIs in rats under weightlessness. The bone protective effects of D-mannose were mediated by inhibiting osteoclast cell fusion. Our findings provide a potential strategy to protect against bone loss and UTIs during space missions.

Keyphrases

bone loss
single cell
signaling pathway
cell therapy
stem cells
mouse model
mesenchymal stem cells
postmenopausal women
bone regeneration