The Maximum-Tolerated Dose and Pharmacokinetics of a Novel Chemically Modified Curcumin in Rats.
Heta Dinesh BhattSteve A McClainHsi-Ming LeeThomas ZimmermanJie DengFrancis JohnsonYing GuLorne M GolubPublished in: Journal of experimental pharmacology (2022)
In conclusion, CMC 2.24, orally administered to rats once a day, appears to be safe and effective at a wide range of doses, consistent with efficacy previously demonstrated in studies on animal models of various collagenolytic diseases, such as periodontitis, diabetes and cancer.