CCR9 initiates epithelial-mesenchymal transition by activating Wnt/β-catenin pathways to promote osteosarcoma metastasis.

Haoran KongWenhui YuZhuning ChenHaonan LiGuiwen YeJiacong HongZhongyu XieKeng ChenYanfeng WuHuiyong Shen

Published in: Cancer cell international (2021)

Our findings suggest that CCR9 promotes EMT by activating Wnt/β-catenin pathways to promote OS metastasis. CCR9 may be a promising therapeutic target to inhibit lung metastasis and serve as a novel prognostic marker for OS.

Keyphrases

epithelial mesenchymal transition
signaling pathway
cell proliferation
transforming growth factor
dendritic cells
regulatory t cells
stem cells