Brain myelin water fraction is associated with APOE4 allele status in patients with cognitive impairment.
Mina ParkHong Pyo LeeJunghyeob KimDong Hyun KimYeonsil MoonWon Jin MoonPublished in: Journal of neuroimaging : official journal of the American Society of Neuroimaging (2021)
T2* GRE-based MWF imaging can reveal myelin loss, particularly in NAWM, in cognitively impaired patients among APOE4 carriers. In vivo MWF in NAWM might be a novel imaging marker of Alzheimer's disease, for clarifying the interactions between the white matter and cognitive dysfunction with respect to the APOE4 status.
Keyphrases
- white matter
- cognitive decline
- cognitive impairment
- high resolution
- end stage renal disease
- high fat diet
- multiple sclerosis
- mild cognitive impairment
- newly diagnosed
- chronic kidney disease
- ejection fraction
- peritoneal dialysis
- genome wide
- type diabetes
- gene expression
- brain injury
- skeletal muscle
- mass spectrometry
- metabolic syndrome
- insulin resistance
- blood brain barrier