Induction of diabetes in cynomolgus monkey with one shot of analytical grade streptozotocin.

Zhengzhao LiuYing LuWenbao HuHidetaka HaraYifan DaiZhiming CaiLisha Mou

Published in: Animal models and experimental medicine (2020)

In summary, we established a safe and reproducible STZ-induced diabetic cynomolgus monkey model for islet transplantation which will be used to develop novel approaches for the treatment of diabetes.

Keyphrases

diabetic rats
type diabetes
oxidative stress
cardiovascular disease
glycemic control
high fat diet
high glucose
stem cells
drug induced
insulin resistance
cell therapy
mass spectrometry
liquid chromatography
endothelial cells