Berberine as a potential enhancer for 5-ALA-mediated fluorescence in glioblastoma: increasing detectability of infiltrating glioma stem cells to optimize 5-ALA-guided surgery.

Yoshihiro OhtsukaSatoshi SuehiroAkihiro InoueTakanori OhnishiMasahiro NishikawaDaisuke YamashitaHajime YanoMohammed E ChoudhurySaya OzakiOltea SampetreanHideyuki SayaHideaki WatanabeJunya TanakaTakeharu Kunieda

Published in: Journal of neurosurgery (2024)

BBR enhanced 5-ALA-mediated PpIX fluorescence by upregulating and activating ALAS1 through deregulation of negative feedback inhibition by heme. BBR is a clinically used drug with no side effects. BBR is expected to significantly augment fluorescence-guided surgery and photodynamic therapy.

Keyphrases

photodynamic therapy
minimally invasive
stem cells
single molecule
coronary artery bypass
energy transfer
surgical site infection
signaling pathway
transcription factor
coronary artery disease
mesenchymal stem cells
cell therapy
electronic health record