Variability of Primary Sjögren's Syndrome Is Driven by Interferon α and Interferon α Blood Levels Are Associated With the Class II HLA-DQ Locus.
Diana TrutschelPierre BostXavier MarietteVincent BondetAlba LlibreCeline PossemeBruno CharbitChristian W ThorballRoland JonssonChristopher J LessardRenaud FeltenWan Fai NgLucienne ChatenoudHélène DumortierJean SibiliaJacques FellayKarl A BrokstadSilke AppelJessica R TarnLluis Quintana-MurciMichael MingueneauNicolas MeyerDarragh DuffyBenno SchwikowskiJacques-Eric Gottenbergnull nullPublished in: Arthritis & rheumatology (Hoboken, N.J.) (2022)
We identified the predominance of IFNα as a driver of primary SS variability, with IFNα demonstrating an association with HLA gene polymorphisms.