BACKGROUND: How to determine team composition is one of many key topics when developing humanity's next deep space exploration programs. Behavioral health and performance among spaceflight teams are key aspects impacted by team composition and cohesiveness. METHODS: This narrative review highlights areas of consideration for building cohesive teams in long duration spaceflight environments. The authors gathered information from a variety of team-behavior related studies that focused on team composition, cohesion, and dynamics, as well as others topics such as faultlines and subgroups, diversity, personality traits, personal values, and crew compatibility training. RESULTS: The literature suggests that team cohesion occurs more easily when individuals are similar to one another, and deep-level variables such as personality and personal values have a greater impact on crew compatibility than surface level variables such as age, nationality, or gender. Diversity can have both positive and negative impacts on team cohesiveness. CONCLUSION: Team composition, as well as pre-mission conflict resolution training can greatly impact group cohesion. This review aims to map areas of concern and assist with crew planning for long duration spaceflight missions. Gangeme A, Simpson B, De La Torre GG, Larose TL, Diaz-Artiles A. A comprehensive look behind team composition for long duration spaceflight . Aerosp Med Hum Perform. 2023; 94(6):457-465.