Inverse Probability of Treatment Weighting and Confounder Missingness in Electronic Health Record-based Analyses: A Comparison of Approaches Using Plasmode Simulation.
Daniel T VaderRonac MamtaniYun LiSandra D GriffithGregory S CalipRebecca A HubbardPublished in: Epidemiology (Cambridge, Mass.) (2023)
Our results support multiple imputation and PS calibration approaches to missingness in missing completely at random or missing at random confounder variables in EHR-based IPTW comparative effectiveness analyses, even with missingness ≥50%. PS calibration represents a computationally efficient alternative to multiple imputation.