Adaptive single-KIR + NKG2C + NK cells expanded from select superdonors show potent missing-self reactivity and efficiently control HLA-mismatched acute myeloid leukemia.
Alvaro Haroun-IzquierdoMarianna VincentiHerman NetskarHanna van OoijenBin ZhangLaura BendzickMinoru KanayaPouria MomayyeziShuo LiMerete Thune WiigerHanna Julie HoelSilje Zandstra KrokeideVeronika KremerGeir TjonnfjordStéphanie BerggrenKristina WikströmPontus BlombergEvren AliciMartin FelicesBjörn ÖnfeltPetter HöglundBahram ValamehrHans-Gustaf LjunggrenAndreas BjörklundQuirin HammerLise KvebergFrank CichockiJeffrey S MillerKarl-Johan MalmbergEbba SohlbergPublished in: Journal for immunotherapy of cancer (2022)
These preclinical data demonstrate the feasibility of off-the-shelf therapy with a non-engineered, yet highly specific, NK cell population with full missing-self recognition capability.