GqPCR-stimulated dephosphorylation of AKT is induced by an IGBP1-mediated PP2A switch.

Guy NadelZhong YaoEhud WainsteinIzel CohenIdo Ben-AmiAmir SchajnovitzGalia Maik-RachlineZvi NaorBenjamin A HorwitzRony Seger

Published in: Cell communication and signaling : CCS (2022)

Our results show a stimulated shift of PP2Ac from PI3K to AKT termed "PP2A switch" that represses the PI3K/AKT pathway, providing a unique mechanism of GPCR-stimulated dephosphorylation. Video Abstract.

Keyphrases

signaling pathway
cell proliferation
drug discovery