Therapeutic Effects of Retinoic Acid in Lipopolysaccharide-Induced Cardiac Dysfunction: Network Pharmacology and Experimental Validation.
Xi WangChang KongPan LiuBaofeng ZhouWujun GengHongli TangPublished in: Journal of inflammation research (2022)
Network pharmacological method offers a predicative strategy to explore the treatment efficacy and causal links of RA in endotoxemic myocarditis. Through experimental verification, we discover that RA can reduce lipopolysaccharide-induced cardiac dysfunction by regulating the PI3K-Akt signaling pathway and key genes.
Keyphrases
- lipopolysaccharide induced
- inflammatory response
- signaling pathway
- rheumatoid arthritis
- left ventricular
- oxidative stress
- disease activity
- genome wide
- ankylosing spondylitis
- pi k akt
- epithelial mesenchymal transition
- systemic lupus erythematosus
- interstitial lung disease
- combination therapy
- transcription factor
- bioinformatics analysis