SKP2 knockout in Rb1/p53 deficient mouse models of osteosarcoma induces immune infiltration and drives a transcriptional program with a favorable prognosis.

Alexander FerrenaJichuan WangRanxin ZhangBurcu Karadal-FerrenaWaleed Al-HardanSwapnil SinghHasibagan BorjihanEdward SchwartzHongling ZhaoRui YangDavid GellerBang HoangDeyou Zheng

Published in: bioRxiv : the preprint server for biology (2023)

inhibition may lead to improved immune activation and potential treatment.

Keyphrases

mouse model
gene expression
transcription factor
oxidative stress
heat shock
risk assessment
combination therapy