EpiFactors 2022: expansion and enhancement of a curated database of human epigenetic factors and complexes.
Daria MarakulinaIlya E VorontsovIvan V KulakovskiyAndreas LennartssonFinn DrabløsYulia A MedvedevaPublished in: Nucleic acids research (2022)
We present an update of EpiFactors, a manually curated database providing information about epigenetic regulators, their complexes, targets, and products which is openly accessible at http://epifactors.autosome.org. An updated version of the EpiFactors contains information on 902 proteins, including 101 histones and protamines, and, as a main update, a newly curated collection of 124 lncRNAs involved in epigenetic regulation. The amount of publications concerning the role of lncRNA in epigenetics is rapidly growing. Yet, the resource that compiles, integrates, organizes, and presents curated information on lncRNAs in epigenetics is missing. EpiFactors fills this gap and provides data on epigenetic regulators in an accessible and user-friendly form. For 820 of the genes in EpiFactors, we include expression estimates across multiple cell types assessed by CAGE-Seq in the FANTOM5 project. In addition, the updated EpiFactors contains information on 73 protein complexes involved in epigenetic regulation. Our resource is practical for a wide range of users, including biologists, bioinformaticians and molecular/systems biologists.
Keyphrases
- dna methylation
- gene expression
- health information
- genome wide
- single cell
- endothelial cells
- transcription factor
- binding protein
- stem cells
- adverse drug
- rna seq
- emergency department
- cell therapy
- long non coding rna
- machine learning
- amino acid
- protein protein
- single molecule
- small molecule
- bioinformatics analysis
- artificial intelligence