Efficient generation of patient-matched malignant and normal primary cell cultures from clear cell renal cell carcinoma patients: clinically relevant models for research and personalized medicine.
Nazleen C LoboCraig GedyeAnthony J ApostoliKevin R BrownJoshua PatersonNatalie StickleMichael RobinetteNeil FleshnerRobert J HamiltonGirish KulkarniAlexandre ZlottaAndrew EvansAntonio FinelliJason MoffatMichael A S JewettLaurie AillesPublished in: BMC cancer (2016)
The ability to establish primary cultures of ccRCC cells and matched normal kidney epithelial cells from almost every patient provides a resource for future development of novel therapies and personalized medicine for ccRCC patients.