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Efficient generation of patient-matched malignant and normal primary cell cultures from clear cell renal cell carcinoma patients: clinically relevant models for research and personalized medicine.

Nazleen C LoboCraig GedyeAnthony J ApostoliKevin R BrownJoshua PatersonNatalie StickleMichael RobinetteNeil FleshnerRobert J HamiltonGirish KulkarniAlexandre ZlottaAndrew EvansAntonio FinelliJason MoffatMichael A S JewettLaurie Ailles
Published in: BMC cancer (2016)
The ability to establish primary cultures of ccRCC cells and matched normal kidney epithelial cells from almost every patient provides a resource for future development of novel therapies and personalized medicine for ccRCC patients.
Keyphrases
  • end stage renal disease
  • ejection fraction
  • newly diagnosed
  • chronic kidney disease
  • peritoneal dialysis
  • case report
  • stem cells
  • signaling pathway
  • cell death
  • endoplasmic reticulum stress