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Cephaloliverols A and B, two sterol-hybrid meroterpenoids from Cephalotaxus oliveri .

Chunyu JiangXiaojie FanDeli ZouZhan-Lin LiTong HanBin LinHui-Ming HuaDa-Hong Li
Published in: Organic & biomolecular chemistry (2022)
Cephaloliverols A (1) and B (2), two meroterpenoids based on a sterol and an abietane diterpene possessing a dioxane ring, were isolated from the twigs and leaves of Cephalotaxus oliveri . Their structures were established by spectroscopic analysis and quantum chemical calculation. 1 and 2 represent the first sterol-hybrid meroditerpenoids. The two compounds and their precursors decreased NO production in a dose-dependent manner in LPS-stimulated RAW 264.7 macrophages.
Keyphrases
  • molecular docking
  • inflammatory response
  • molecular dynamics
  • high resolution
  • mass spectrometry
  • molecular dynamics simulations
  • essential oil