Autophagy has received increased attention as a conserved process governing cellular energy and protein homeostasis that is thus relevant in a range of physiological and pathophysiological conditions. Recently, autophagy has also been linked to depression, mainly through its involvement in the action of antidepressants. Some antidepressant drugs and psychotropic medication have been reported to exert beneficial effects in other diseases, for example, in cancer and neurodegenerative diseases. This review collates the evidence for the hypothesis that autophagy contributes to the effects of antidepressants beyond depression treatment.
Keyphrases
- cell death
- major depressive disorder
- endoplasmic reticulum stress
- signaling pathway
- oxidative stress
- depressive symptoms
- bipolar disorder
- healthcare
- working memory
- sleep quality
- squamous cell carcinoma
- transcription factor
- emergency department
- young adults
- replacement therapy
- squamous cell
- binding protein
- childhood cancer
- drug induced
- smoking cessation