Atractylodes macrocephala Koidz Alleviates Symptoms in Zymosan-Induced Irritable Bowel Syndrome Mouse Model through TRPV1, NaV1.5, and NaV1.7 Channel Modulation.
Na-Ri ChoiWoo-Gyun ChoiJong-Hwan LeeJoon ParkYun-Tai KimRaju DasJoo Han WooByung-Joo KimPublished in: Nutrients (2024)
(1) Background: Irritable bowel syndrome (IBS) is a common disease in the gastrointestinal (GI) tract. Atractylodes macrocephala Koidz (AMK) is known as one of the traditional medicines that shows a good efficacy in the GI tract. (2) Methods: We investigated the effect of AMK in a network pharmacology and zymosan-induced IBS animal model. In addition, we performed electrophysiological experiments to confirm the regulatory mechanisms related to IBS. (3) Results: Various characteristics of AMK were investigated using TCMSP data and various analysis systems. AMK restored the macroscopic changes and weight to normal. Colonic mucosa and inflammatory factors were reduced. These effects were similar to those of amitriptyline and sulfasalazine. In addition, transient receptor potential (TRP) V1, voltage-gated Na + (NaV) 1.5, and NaV1.7 channels were inhibited. (4) Conclusion: These results suggest that AMK may be a promising therapeutic candidate for IBS management through the regulation of ion channels.
Keyphrases
- irritable bowel syndrome
- mouse model
- high glucose
- diabetic rats
- drug induced
- body mass index
- physical activity
- endothelial cells
- spinal cord injury
- machine learning
- climate change
- depressive symptoms
- risk assessment
- binding protein
- cerebral ischemia
- high resolution
- body weight
- brain injury
- blood brain barrier
- ulcerative colitis