Hyperglycaemia-associated macrophage pyroptosis accelerates periodontal inflamm-aging.

Pengfei ZhaoZiqi YueLulingxiao NieZhihao ZhaoQian WangJiao ChenQi Wang

Published in: Journal of clinical periodontology (2021)

Hyperglycaemia could initially induce macrophage pyroptosis and lead to cellular senescence, thereby critically contributing to periodontal pathogenesis in diabetes. In particular, NLRC4 phosphorylation could be a potential therapeutic target for the inhibition of this process.

Keyphrases

nlrp inflammasome
adipose tissue
type diabetes
cardiovascular disease
dna damage
endothelial cells
stress induced
protein kinase
metabolic syndrome
weight loss
oxidative stress