Histopathological factors versus margin size in single colorectal liver metastases: Does a 1-cm margin size matter?
Gilton Marques FonsecaEvandro S de MelloSheila F FarajJaime A P KrugerVagner B JeismannFabricio F CoelhoVenancio A F AlvesPaulo HermanPublished in: Scandinavian journal of surgery : SJS : official organ for the Finnish Surgical Society and the Scandinavian Surgical Society (2022)
In colorectal liver metastasis resection, the absence of tumor pseudocapsule was significantly associated with shorter overall survival and disease-free survival and hepatic recurrence. However, margins larger than 10 mm did not offer survival benefit when other pathologic negative prognostic factors were concomitantly analyzed, reinforcing the idea that biology, rather than margin size, is crucial for prognosis.