Pharmacodynamics of cerebrospinal fluid asparagine after asparaginase.
John C PanettaYiwei LiuTeodoro BottiglieriErland ArningCheng ChengSeth E KarolJun J YangYinmei ZhouHiroto InabaChing-Hon PuiSima JehaMary V RellingPublished in: Cancer chemotherapy and pharmacology (2021)
The number of pegaspargase doses has a stronger influence on CSF asparagine depletion than did dosage, pegaspargase depleted CSF asparagine longer than erwinase, and CSF asparagine depletion may prevent CNS relapses.
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