Genetic architecture of cardiometabolic risks in people living with HIV.
Haoxiang ChengAnshuman SewdaCarla Marquez-LunaSierra R WhiteBridget M WhitneyJessica Williams-NguyenRobin M NanceWon Jun LeeMari M KitahataMichael S SaagAmanda WilligJoseph J EronW Christopher MathewsPeter W HuntRichard D MooreAllison WebelKenneth H MayerJoseph A DelaneyPaul K CraneHeidi M CraneKe HaoInga PeterPublished in: BMC medicine (2020)
Our findings suggest that genetic loci involved in the regulation of the immune system and predisposition to risky behaviors contribute to dyslipidemia in the presence of HIV infection. Moreover, we demonstrate the utility of the European-based and multiethnic PRS for stratification of PLWH at a high risk of cardiometabolic diseases who may benefit from preventive therapies.