Role of perilesional edema and tumor volume in the prognosis of non-small cell lung cancer (NSCLC) undergoing radiosurgery (SRS) for brain metastases.

Valerio NardoneSara NanniPierpaolo PastinaClaudia VinciguerraAlfonso CerasePierpaolo CorrealeCesare GuidaAntonio GiordanoPaolo TiniAlfonso ReginelliSalvatore CappabiancaLuigi Pirtoli

Published in: Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] (2019)

Our study, although with the limitations of a monocentric retrospective study analyzing a small cohort of patients, suggests the role of PE/GTV ratio for the development of new BMs. TV also seems to be correlated with OS, together with known clinical prognosticators. These findings, if validated in a larger prospective dataset, could help in selecting patients for the most suitable RT modality (or systemic therapy approach).

Keyphrases

brain metastases
small cell lung cancer
end stage renal disease
ejection fraction
mesenchymal stem cells
patient reported outcomes
bone marrow
drug induced
replacement therapy