Lymphocyte Infiltration Score and Spatial Characteristics Refined the Prognosis and Denosumab Treatment Responsiveness Indicators for Giant Cell Tumor of Bone.

Hai-Lin WuChao XiaFu-Sheng LiuBo-Yv ZhengHua-Qing NiuGuo-Qiang ZhuMing-Xiang ZouBo-Wen Zheng

Published in: JCO precision oncology (2024)

These findings suggest that LIS is a reliable predictive tool for clinically relevant outcomes and response to denosumab therapy in patients with GCTB. These parameters may prove to be useful in guiding prognostic risk stratification and therapeutic optimization for patients.

Keyphrases

giant cell
bone mineral density
end stage renal disease
ejection fraction
newly diagnosed
peritoneal dialysis
patient reported outcomes
body composition
skeletal muscle
metabolic syndrome
adipose tissue
replacement therapy
bone loss