Discovery and characterization of the tubercidin biosynthetic pathway from Streptomyces tubercidicus NBRC 13090.

Yan LiuRong GongXiaoqin LiuPeichao ZhangQi ZhangYou-Sheng CaiZixin DengMargit WinklerJianguo WuWenqing Chen

Published in: Microbial cell factories (2018)

These findings lay a foundation for the rational generation of TBN analogs through synthetic biology strategy, and also open the way for the target-directed search of TBN-related antibiotics.

Keyphrases

small molecule
minimally invasive
molecular docking
high throughput