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Effects of quercetin, sitagliptin alone or in combination in testicular toxicity induced by doxorubicin in rats.

Zheen Aorahman AhmedAso Nihad AbtarHemn Hassan OthmanTavga Ahmed Aziz
Published in: Drug design, development and therapy (2019)
The results suggest quercetin/sitagliptin combination as a promising therapeutic modality for attenuation of DOX-induced testicular toxicity in rats, and the main mechanism involved in such effect could be due to the antioxidant and anti-inflammatory properties of both agents.
Keyphrases
  • anti inflammatory
  • oxidative stress
  • diabetic rats
  • germ cell
  • high glucose
  • cancer therapy
  • endothelial cells
  • stress induced