Beta-cell function is disrupted in patients with systemic lupus erythematosus.

Alicia García-DortaJuan Carlos Quevedo-AbeledoÍñigo Rua-FigueroaAntonia M de Vera-GonzálezAlejandra González-DelgadoLilian Medina-VegaAgustín F González-RiveroFelix Francisco-HernándezMiguel A González-GayIván Ferraz-Amaro

Published in: Rheumatology (Oxford, England) (2021)

Among patients with SLE, proinsulin-processing metabolites, a marker of beta-cell disruption, are upregulated compared with matched controls. This disproportionate hyperproinsulinemia can be explained by the damage produced by the disease and occurs independently of prednisone use.

Keyphrases

systemic lupus erythematosus
single cell
ms ms
cell therapy
oxidative stress
disease activity
resting state
stem cells
rheumatoid arthritis
functional connectivity