Tadalafil attenuates hypotonicity-induced Ca2+ influx via TRPV2 and TRPV4 in primary rat bladder urothelial cell cultures.

Xiao DongHiroshi NakagomiTatsuya MiyamotoTatsuya IharaSatoru KiraNorifumi SawadaTakahiko MitsuiMasayuki Takeda

Published in: Neurourology and urodynamics (2018)

Tadalafil attenuates Ca2+ influx via TRPV4 and TRPV2, and inhibits ATP release in the bladder urothelium. These findings indicate that tadalafil functions as an inhibitor of urothelial signal transduction.

Keyphrases

urinary tract
neuropathic pain
spinal cord injury
lower urinary tract symptoms
benign prostatic hyperplasia
high grade
oxidative stress
high glucose
drug induced
mesenchymal stem cells
bone marrow