Liver phenotypes in PCOS: analysis of exogenous and inherited risk factors for liver injury in two European cohorts.

Wiktor SmykIfigeneia PapapostoliMichał ŻorniakPanagiotis SklavounosŁukasz BlukaczPaweł MadejAndreani KoutsouSusanne N WeberBettina Friesenhahn-OchsMaciej CebulaJoanna BosowskaErich-Franz SolomayerMarek Hartleb Piotr Milkiewicz Matthias Christian ReichertCaroline S StokesMarcin Krawczyk

Published in: Liver international : official journal of the International Association for the Study of the Liver (2023)

FLD is common in females with PCOS. Its extent is modulated by both genetic and metabolic risk factors. Genetic variants associated with FLD might help to stratify the risk of liver disease progression in women suffering from PCOS.

Keyphrases

polycystic ovary syndrome
liver injury
drug induced
risk factors
insulin resistance
genome wide
adipose tissue
metabolic syndrome
type diabetes
skeletal muscle
dna methylation
gene expression
pregnant women