Understanding Molecular Mechanisms and Identifying Key Processes in Chronic Radiation Cystitis.
Clément BrossardAnne-Charlotte LefrancJean-Marc SimonMarc BenderitterFabien MilliatAlain ChapelPublished in: International journal of molecular sciences (2022)
Chronic radiation cystitis (CRC) is a consequence of pelvic radiotherapy and affects 5-10% of patients. The pathology of CRC is without curative treatment and is characterized by incontinence, pelvic pain and hematuria, which severely degrades patients' quality of life. Current management strategies rely primarily on symptomatic measures and have certain limitations. Thanks to a better understanding of the pathophysiology of radiation cystitis, studies targeting key manifestations such as inflammation, neovascularization and cell atrophy have emerged and are promising avenues for future treatment. However, the mechanisms of CRC are still better described in animal models than in human models. Preclinical studies conducted to elucidate the pathophysiology of CRC use distinct models and are most often limited to specific processes, such as fibrosis, vascular damage and inflammation. This review presents a synthesis of experimental studies aimed at improving our understanding of the molecular mechanisms at play and identifying key processes in CRC.
Keyphrases
- end stage renal disease
- oxidative stress
- newly diagnosed
- ejection fraction
- prognostic factors
- endothelial cells
- peritoneal dialysis
- radiation induced
- stem cells
- rectal cancer
- squamous cell carcinoma
- spinal cord
- cell therapy
- single cell
- mesenchymal stem cells
- drug delivery
- vascular endothelial growth factor
- neuropathic pain
- bone marrow
- induced pluripotent stem cells
- patient reported
- cancer therapy
- postoperative pain