Hyperhomocysteinemia is key for increased susceptibility to PND in aged mice.
Guangchao ZhaoJiao DengYuan ShenPeng ZhangHailong DongZhongcong XieLize XiongPublished in: Annals of clinical and translational neurology (2019)
Serum homocysteine accumulation is a fundamental cause for increased susceptibility of PND in aged mice. Preoperative diet supplementation of VitB12 + FA can effectively reduce PND in aged mice, which may be a promising prophylaxis treatment in clinical settings.