iPSC-derived natural killer cells expressing the FcγR fusion CD64/16A can be armed with antibodies for multitumor antigen targeting.

Kristin M SnyderKate J DixonZachary DavisMartin HoskingGeoffrey HartMelissa KhawAnders MatsonRyan BjordahlBryan HancockSoheila ShirinbakJeffrey S MillerBahram ValamehrJianming WuBruce Walcheck

Published in: Journal for immunotherapy of cancer (2023)

iNK cells expressing CD64/16A provide an off-the-shelf multiantigen targeting platform to address tumor heterogeneity and mitigate antigen escape.

Keyphrases

natural killer cells
induced apoptosis
cancer therapy
cell cycle arrest
nk cells
single cell
high throughput
oxidative stress
cell proliferation