Synergic effect of simvastatin in combination with amphotericin B against environmental strains of Cryptococcus neoformans from northeastern Brazil: a prospective experimental study.
Tássio Henrique Sousa SilvaClaudiane Vansoski AraújoKhelvin Myner da Costa SantosNathanael Dos Santos AlvesThayse Haylene Soares GomesAndressa Kelly Ferreira E SilvaNayra Cristina Lira Dos Santos SilvaEvandro César Bezerra Damasceno JúniorAndressa Maria Aguiar de CarvalhoMaria Gabriela Araújo MendesHenrique Barros CaminhaTatiane Caroline DaboitThatiana Bragine FerreiraLeonardo Eurípedes de Andrade SilvaMario León Silva-VergaraKennio Ferreira-PaimFernanda Machado FonsecaPublished in: Sao Paulo medical journal = Revista paulista de medicina (2020)
These results demonstrate that simvastatin should be considered to be a therapeutic alternative, capable of potentiating the action of amphotericin B. However, further studies are necessary to clarify the real effect of simvastatin as an antifungal agent.
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