By using PCLS and neutrophils from young and old mice as immunocompetent ex vivo test systems, we could mimic dysregulated immune responses upon aging on levels of gene expression, cytokine production, and receptor expression. The results furthermore reflect the exacerbation of inflammation upon P. aeruginosa lung infection as a result of inflamm-aging in old age.
Keyphrases
- inflammatory response
- gene expression
- immune response
- chronic obstructive pulmonary disease
- oxidative stress
- toll like receptor
- dna methylation
- lipopolysaccharide induced
- lps induced
- respiratory failure
- high fat diet induced
- middle aged
- dendritic cells
- type diabetes
- skeletal muscle
- community acquired pneumonia
- mechanical ventilation
- extracorporeal membrane oxygenation