Neospora caninum: Structure and Fate of Multinucleated Complexes Induced by the Bumped Kinase Inhibitor BKI-1294.
Pablo WinzerNicoleta AnghelDennis ImhofVreni BalmerLuis-Miguel Ortega-MoraKayode K OjoWesley C Van VoorhisJoachim MüllerAndrew HemphillPublished in: Pathogens (Basel, Switzerland) (2020)
CDPK1 has a dynamic distribution depending on whether parasites are located within a host cell or outside. During MNC-to-tachyzoite reconversion newly formed tachyzoites are generated directly from MNCs through zoites of unknown surface antigen composition. Further in vivo studies are needed to determine if MNCs could lead to a persistent reservoir of infection after BKI treatment.