The impact of sepsis on hepatic drug metabolism in critically ill patients: a narrative review.

Tim Mj EwoldtAlan AbdullaNicole HunfeldLetao LiTim J L SmeetsDiederik GommersBirgit C P KochHenrik Endeman

Published in: Expert opinion on drug metabolism & toxicology (2022)

Limited research has been conducted on drug metabolism in the sepsis population, with some trials having researched healthy individuals using endotoxin injections. Notwithstanding this limitation, hepatic drug metabolism seems to be decreased for certain drugs in sepsis. More research on the pharmacokinetic behavior of hepatic metabolized drugs in sepsis is warranted, using inflammatory biomarkers, hemodynamic changes, mechanical ventilation, organ support, and catecholamine infusion as possible confounders.

Keyphrases

intensive care unit
mechanical ventilation
septic shock
acute kidney injury
acute respiratory distress syndrome
drug induced
adverse drug
ultrasound guided